Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapy

Cancer ◽  
1984 ◽  
Vol 53 (5) ◽  
pp. 1049-1057 ◽  
Author(s):  
Stuart J. Schnitt ◽  
James L. Connolly ◽  
Jay R. Harris ◽  
Samuel Hellman ◽  
Richard B. Cohen
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Stage I ◽  
Primary Radiation ◽  
Early Local Recurrence

Primary radiation therapy for stage I and II breast cancer

1988 ◽  
Vol 4 (4) ◽  
pp. 244-249 ◽  
Author(s):  
Scot Fisher ◽  
Luther W. Brady
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Stage I ◽  
Primary Radiation

Time course and prognosis of local recurrence following primary radiation therapy for early breast cancer.

1984 ◽  
Vol 2 (1) ◽  
pp. 37-41 ◽  
Author(s):  
J R Harris ◽  
A Recht ◽  
R Amalric ◽  
R Calle ◽  
R M Clark ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Early Breast Cancer ◽  
Time Course ◽  
Primary Radiation ◽  
Breast Cancer Patients ◽  
Distant Relapse ◽  
Long Term Follow Up ◽  
Isolated Local Recurrence

The frequency, time course, and prognosis of local recurrence following primary radiation therapy in 152 patients with early breast cancer treated before 1967 were examined. Local recurrence occurred at a constant rate over the first 14 years after treatment. The crude 15-year local recurrence rate was 22%. Of the 30 patients who developed an isolated local recurrence and underwent definitive secondary surgery, the 10-year freedom from distant relapse rate was 50%. These results indicate that breast cancer patients treated by primary radiation therapy require long-term follow-up to detect curable local recurrences.

scholarly journals The impact of sociodemographic factors on the utilization of radiation therapy in breast cancer patients in Estonia: a register-based study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Fereshteh Shahrabi Farahani ◽  
Keiu Paapsi ◽  
Kaire Innos
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Registry ◽  
Psychosocial Support ◽  
Sociodemographic Factors ◽  
Stage I ◽  
Equal Access ◽  
Administrative Databases ◽  
The Impact ◽  
Over Time

Abstract Background Radiation therapy is an important part of multimodal breast cancer treatment. The aim was to examine the impact of sociodemographic factors on radiation therapy use in breast cancer (BC) patients in Estonia, linking cancer registry data to administrative databases. Methods Estonian Cancer Registry provided data on women diagnosed with BC in Estonia in 2007–2018, including TNM stage at diagnosis. Use of radiation therapy within 12 months of diagnosis was determined from Estonian Health Insurance Funds claims, and sociodemographic characteristics from population registry. Receipt of radiation therapy was evaluated over time and by clinical and sociodemographic factors. Poisson regression with robust variance was used to calculate univariate and multivariate prevalence rate ratios (PRR) with 95 % confidence intervals (CI) for receipt of radiation therapy among stage I–III BC patients age < 70 years who underwent primary surgery. Results Overall, of 8637 women included in the study, 4310 (50 %) received radiation therapy within 12 months of diagnosis. This proportion increased from 39 to 58 % from 2007 to 2009 to 2016–2018 (p < 0.001). Multivariate regression analysis showed that compared to women with stage I BC, those with more advanced stage were less likely to receive radiation therapy. Receipt of radiation therapy increased significantly over time and was nearly 40 % higher in 2016–2018 than in 2007–2009. Use of radiation therapy was significantly lower for women with the lowest level of education compared to those with a university degree (PRR 0.88, 95 % CI 0.80–0.97), and for divorced/widowed women (PRR 0.95, 95 % CI 0.91–0.99) and single women (PRR 0.92, 95 % CI 0.86–0.99), compared to married women. Age at diagnosis, nationality and place of residence were not associated with receipt of radiation therapy. Conclusions The study showed considerable increase in the use of radiation therapy in Estonia over the study period, which is in line with increases in available equipment. The lack of geographic variations suggests equal access to therapy for patients living in remote regions. However, educational level and marital status were significantly associated with receipt of radiation therapy, highlighting the importance of psychosocial support in ensuring equal access to care.

scholarly journals 352. Definitive Radiation Therapy for Stage I, II Breast Cancer : Dose Distribution of Open Field Beam-(Part 3)

1991 ◽  
Vol 47 (8) ◽  
pp. 1383
Author(s):  
Manabu Nakata ◽  
Takashi Okada ◽  
Shinsuke Yano ◽  
Naomi Enoki ◽  
Hiroki Nohara
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Open Field ◽  
Dose Distribution ◽  
Stage I

scholarly journals 274. Definitive Radiation Therapy for Stage I, II Breast Cancer : Possibility in Tangential Irradiation for 10 MV X-ray Beams (Part 4)

1992 ◽  
Vol 48 (8) ◽  
pp. 1357
Author(s):  
Manabu Nakata ◽  
Naomi Enoki ◽  
Shinsuke Yano ◽  
Satoshi Fukumoto ◽  
Takashi Okada ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Stage I ◽  
X Ray

Patient preferences concerning the trade-off between the risks and benefits of routine radiation therapy after conservative surgery for early-stage breast cancer.

1997 ◽  
Vol 15 (3) ◽  
pp. 1252-1260 ◽  
Author(s):  
J A Hayman ◽  
D L Fairclough ◽  
J R Harris ◽  
J C Weeks
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Early Stage ◽  
Conservative Surgery ◽  
Sociodemographic Factors ◽  
Early Stage Breast Cancer ◽  
Health States ◽  
Trade Off ◽  
Risks And Benefits

PURPOSE To assess patients' preferences regarding the trade-off between risks and benefits of radiation therapy after conservative surgery for early-stage breast cancer. PATIENTS AND METHODS Utilities (measures of preference) of 97 early-stage breast cancer patients treated with conservative surgery and radiation therapy and 20 medical oncology nurses were assessed for five health states using standard gambles. RESULTS Patients had the highest mean utility for treatment with conservative surgery and radiation therapy without a local recurrence (0.92), intermediate utilities for treatment with conservative surgery alone followed either by no local recurrence or by a local recurrence salvaged by conservative surgery and radiation therapy (0.88 and 0.87, respectively), and the lowest utilities for treatment with or without radiation therapy followed by a local recurrence salvaged by mastectomy and reconstructive surgery (0.82 and 0.81, respectively). All differences between health states' utilities were significant (P < .0001), except between the two intermediate and two lowest rated health states. None of the clinical or sociodemographic factors examined explained more than 5% of the variability in the patients' utilities or their differences. Nurses' utilities were similar to those of the patients. CONCLUSIONS These results strongly suggest that fear of a local recurrence and an actual local recurrence leading to mastectomy have such a negative impact on quality of life that patients are willing to accept the risks and inconvenience of radiation therapy to avoid them. There is also considerable interpatient variability that was not explained by the clinical or sociodemographic factors examined.

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